从2005年到2024年,中国的CC4821 Neisseria meningitidis的致病性变化
Xueping Liu1, Hairui Wang1, Bohan Chen1
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
概括
尼塞利亚脑膜炎克隆复合体4821 (CC4821) 显示出正在演变的致病性. 血清组B菌株表现出增加的粘附和入侵,而B和C血清组显示出增强的亡诱导,需要持续监测.
科学领域:
- 微生物学与传染病的研究
- 细菌病原体的分子流行病学
背景情况:
- 脑膜炎菌 (N. meningitidis) 是导致侵袭性脑膜炎球菌疾病 (IMD) 的原因.
- 克隆复合体4821 (CC4821) 是N. meningitidis在中国的主导血统.
- CC4821血清组B和C菌株之间的致病性差异尚不清楚.
研究的目的:
- 为了评估CC4821 N. meningitidis分离物的分布和致病性.
- 为了比较CC4821血清组B和C菌株的粘附,入侵,炎症反应和亡诱导.
- 根据隔离源,血清组和时间 (2005-2024) 分析致病性趋势.
主要方法:
- 基于来源,血清组和隔离时间的CC4821 N. meningitidis分离物 (2005-2024) 的分析.
- 在体外评估细菌的粘附和入侵能力.
- 测量炎症性细胞因子 (IL-6,IL-8,TNF-α) 的释放.
- 在A549细胞中诱导亡的测试.
主要成果:
- 最近的CC4821血清组B分离物显示患病率,附着性和入侵性增加.
- CC4821血清组C分离物数量减少,粘附和入侵能力降低.
- 这两种血清组都会诱导显著的炎症性细胞因子释放 (IL-6,IL-8,TNF-α).
- 最近的侵袭性分离物 (B和C) 和运输分离物显示,与早期菌株相比,亡诱导增加.
结论:
- CC4821血清组B菌株表现出增强的呼吸道殖民和传播潜力.
- CC4821血清组C菌株,尽管粘合力减弱,仍然是一个潜在的风险.
- 持续监测两个血清组,特别是无症状携带者,对于管理IMD风险至关重要.
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