Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Master Transcription Regulators02:23

Master Transcription Regulators

8.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.0K
Negative Regulator Molecules01:23

Negative Regulator Molecules

38.8K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.8K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

6.1K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K
Lineage Commitment01:21

Lineage Commitment

4.5K
Commitment is the  process whereby stem cells:
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.

Journal of experimental & clinical cancer research : CR·2022
Same author

Effects of different modes of exercise on skeletal muscle mass and function and IGF-1 signaling during early aging in mice.

The Journal of experimental biology·2022
Same author

Optimal Control of False Information Clarification System under Major Emergencies Based on Differential Game Theory.

Computational intelligence and neuroscience·2022
Same author

Ionothermal Synthesis of Fully Conjugated Covalent Organic Frameworks for High-Capacity and Ultrastable Potassium-Ion Batteries.

Advanced materials (Deerfield Beach, Fla.)·2022
Same author

Circ-OMAC drives metastasis in oral squamous cell carcinoma.

Oral diseases·2022
Same author

Biodegradation of Dibutyl Phthalate by the New Strain <i>Acinetobacter baumannii</i> DP-2.

Toxics·2022

相关实验视频

Updated: Mar 14, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.6K

蛋白质4.1R调节CCDC26并影响髓性白血病的进展.

Luyang Zhao1, Bowen Li2, Hanhan Li1

  • 1Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, 450052, Henan, Zhengzhou, China.

Cellular signalling
|March 12, 2026
PubMed
概括

蛋白质4.1R通过结合长非编码RNACCDC26抑制髓性白血病,防止其细胞质运输,并抑制MAPK通路. 这一发现为白血病提供了新的治疗点.

关键词:
CCDC26 疾病预防控制中心在 MAPK 信号通道中.骨髓性白血病 (Myeloid Leukemia) 是一种神经性白血病.核武器的扩散蛋白质4.1RR是一种蛋白质.

更多相关视频

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

890
Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

8.1K

相关实验视频

Last Updated: Mar 14, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.6K
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

890
Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

8.1K

科学领域:

  • 血液学 血液学 血液学
  • 分子生物学分子生物学
  • 在瘤学瘤学.

背景情况:

  • 骨髓性白血病涉及异常的骨髓原生细胞增殖,与不清楚的分子驱动因素.
  • 蛋白质4.1R (EPB41) 是其他癌症的瘤抑制剂,但其在髓性白血病中的作用尚不清楚.

研究的目的:

  • 为了研究骨髓性白血病中4.1R蛋白的功能和分子机制.
  • 为了确定下游目标和由蛋白质4.1R.调节的信号通路.

主要方法:

  • 在K562和HEL白血病细胞系中破坏4.1R蛋白.
  • 转录组测序以识别下游分子.
  • RNA下拉和核细胞质分离以研究RNA-蛋白相互作用.

主要成果:

  • 蛋白质4.1R倒置增加了细胞增殖,减少了细胞亡,并促进了S阶段的进入.
  • CCDC26被确定为一个关键的下游长非编码RNA.
  • 蛋白质4.1R在核中直接与CCDC26结合,抑制其细胞质输出和随后的MAPK通路激活.

结论:

  • 蛋白质4.1R通过将CCDC26隔离在细胞核中,从而抑制MAPK信号,从而抑制髓性白血病的进展.
  • 这种机制突显了蛋白质4.1R-CCDC26相互作用在白血病病原发生中的作用.
  • 这些发现为在白血病治疗中准这种途径提供了理论基础.