黑碳可与胎儿循环中的小细胞外囊泡结合检测到
Houman Kahroba1, Kenneth Vanbrabant2, Julian Krauskopf3
1Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; Department of Translational Genomics, GROW School of Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands.
Environment international
|March 12, 2026
概括
黑碳 (BC) 空气污染颗粒与胎儿循环中的细胞外囊泡 (EVs) 相关. 这表明,电动汽车可能会通过胎盘运输污染物,影响胎儿的发育.
科学领域:
- 环境健康 环境健康
- 围产儿医学 围产儿医学
- 纳米毒理学研究
背景情况:
- 产前暴露于环境空气污染,特别是黑碳 (BC),与不良妊娠结果和神经发育障碍有关.
- 通过胎盘从母亲转移到胎儿的纳米粒子传输的精确机制仍然不太清楚.
研究的目的:
- 调查黑碳 (BC) 与胎儿循环中的小细胞外囊泡 (sEV) 的存在和关联.
- 探索sEVs在吸入纳米颗粒的体外转移中的潜在作用.
主要方法:
- 使用无标签的两光子显微镜可视化与单个SEVs相关的BC.
- 从20对母婴对的带血中分离的sEVs.
- 在总sEV和特定的胎盘和胎儿大脑衍生的sEV子集中的量化BC-sEV关联.
主要成果:
- 在胎儿循环中检测到与sEVs相关的黑碳 (BC).
- 在27%的带血sEV中观察到BC-sEV相关性.
- 在胎盘 (54%) 和胎儿大脑衍生的 (68%) sEV子集中发现了更高的BC关联,在脑衍生的囊泡中具有显著的同局部化 (> 90%).
结论:
- 这些发现为胎儿循环中的sEV丰富制剂中BC检测提供了证据.
- 表明sEV相关载体在BC纳米颗粒的体外转移中可能发挥作用.
- 超胎位粒子转移的主导机制需要进一步研究.
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