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Eman I Hassanen¹, Ahmed A Sherif¹, Zienab E Eldin²

¹Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Veterinary parasitology

|March 12, 2026

概括

纳林因 (NG),特别是其纳米配方 (NGNP),显著增强了ivermectin的作用.

科学领域:

兽医寄生虫学兽医寄生虫学
动物科学动物科学
药理学药理学是指药理学的学科.

背景情况:

由 *Sarcoptes scabiei* 引起的 Sarcoptic mange 是子的一种严重的寄生性皮肤疾病.
由于生产率和繁殖率下降,这种疾病在子生产中造成了巨大的经济损失.
现有的治疗方法可能有局限性,需要探索增强的治疗策略.

研究的目的:

为了评估纳林丁 (NG) 的疗效,在纯和纳米配方 (NGNPs) 状态下,作为治疗子肉骨的艾弗梅克丁 (IVM) 的辅助剂.
评估这些联合治疗对临床症状,生长性能,寄生虫负载和宿主免疫反应的影响.

主要方法:

25只受感染的子被分为五组:对照组,单独使用ivermectin (IVM),IVM+口服NG,IVM+口服NGNP.
治疗持续了28天,通过临床,寄生虫学,生长,炎症基因表达,遗传病学和免疫学参数评估了杀虫剂疗效.
分析了包括NF-κB,TNF-α,IL-1β,iNOS和CD3在内的关键炎症标志物.

主要成果:

组合疗法,特别是IVM + NGNP,显著改善了子的生长性能和加速皮肤愈合.
在IVM + NGNPs组中,在治疗后14天内实现了寄生虫消除.
NGNP通过降低NF-κB,TNF-α和IL-1β转录水平来表现出抗炎作用.

结论:

每日口服补充纳米配制的纳灵素 (NGNP) 作为强效的增强剂,用于治疗子肉骨.
组合疗法促进了寄生虫的根除,加速了皮肤的恢复,增强了免疫力,保护了器官,并改善了子的整体生长性能.
NGNP代表了一种有前途的策略,可以增强ivermectin对子*Sarcoptes scabiei*感染的疗效.

关键词:

皮肤炎是一种皮肤炎.基因表达基因表达基因表达我从来没有使用过mectin.纳米技术纳米技术纳林丁 (Naringin) 是一个古老的语言.萨尔科普菌的病是什么意思

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