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卷度后对比T1旋回声与梯度回忆回声MRI序列用于检测大脑转移:系统性审查和元分析
Anass Benomar1, Sukhmanjit S Ghumman2, Youcef Ouahdi2
1From the Department of Medical Imaging (A.B., S.S., C.H., P.J.M.), Radiation Oncology (H.S., K.L.Z., C.-L.T., J.D., H.C., D.D.,A.S.), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; Department of Radiology (S. S.G.), Jewish General Hospital, McGill University Health Centre, Montreal, QC, Canada; Faculty of Medicine (Y.O.), University of Montreal, Montreal, QC, Canada; Departments of Radiology and Neurologic Surgery (S.G.), Mayo Clinic, Rochester, MN, USA and Department of Radiology (Q.F.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. anass.benomar@umontreal.ca.
3D T1 TSE 序列对检测大脑转移的灵敏度高于 GRE 序列,特别是在小病变中. 虽然TSE提供了改善的病变明显性,但它可能会导致稍微更多的错误阳性.
科学领域:
- 神经成像是一种神经成像.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 与对比度增强的3D T1加权MRI是大脑转移检测的标准.
- 基于GRE的序列 (例如,MPRAGE) 在损伤明显性方面存在局限性.
- 基于TSE的3D黑血序列 (例如,SPACE) 越来越多地用于改进病变检测.
研究的目的:
- 为了比较3D T1 TSE与GRE序列用于大脑转移检测的诊断性能.
- 为了评估不同MRI序列的灵敏度,病变明显性和准确性.
主要方法:
- 在MEDLINE,EMBASE,Cochrane Central,Google Scholar和PROSPERO上进行系统的文献搜索.
- 15项研究的元分析,包括544名患者和4338名转移.
- 使用随机效应模型评估诊断准确性,图像质量和评审者之间的一致性.
主要成果:
- 与GRE序列 (76.1%) 相比,TSE序列表现出明显更高的聚合灵敏度 (97.4%).
- 在检测小转移 (<5毫米) 方面,TSE优越,敏感度为96.1%,对GRE的敏感度为58.4%.
- 这两种技术在较大的病变 (≥5毫米) 中都具有可比性.
结论:
- 与GRE序列相比,后对比3D T1 TSE序列为大脑转移提供了更高的灵敏度和病变明显性.
- 对于检测小转移而言,TSE特别有益.
- 略高的TSE错误阳性需要考虑,通常与血管抑制有关.
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