Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

5.6K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
5.6K
Chemical Synapses01:26

Chemical Synapses

12.3K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.3K
Chemical Synapses01:26

Chemical Synapses

6.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
6.8K
The Neuromuscular Junction01:19

The Neuromuscular Junction

21.3K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
21.3K
Neural Regulation01:37

Neural Regulation

44.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.0K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

14.3K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
14.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Analysis of PTEN Antagonistic Peptides (PAPs) in Neuronal Growth and Traumatic Brain Injury (TBI).

Biomacromolecules·2026
Same author

Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass.

Bone research·2026
Same author

A practical and efficient technique for corneal allogenic ring segment implantation: prolene suture-guided insertion.

Cell and tissue banking·2026
Same author

Unveiling the antidiabetic, anti-inflammatory and anti-hemolytic activities of Raphanus sativus leaves through in-vitro and in-silico studies.

Scientific reports·2026
Same author

Use of Silicone Drains to Prevent Pedicle Compression in Edematous Crush Trauma.

Microsurgery·2026
Same author

Hypothalamic atrophy in progressive supranuclear palsy, assessed by convolutional neural network-based automatic segmentation.

Journal of neurology·2026

相关实验视频

Updated: Mar 14, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

3.2K

摩托神经元的抑制突触对神经元活动具有恒常性反应,并调节肌缩侧面硬化病原发生.

Kareen Halablab1,2, Gizem Yartas1, Natalie Dikwella2

  • 1German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, DE.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|March 12, 2026
PubMed
概括

运动神经元 (MN) 中的抑制性突触适应了早期ALS期间MN活动的变化. 抑制这些抑制性连接增加了MN刺激性,并减少了疾病标志物,表明了治疗潜力.

更多相关视频

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

10.4K
Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

7.4K

相关实验视频

Last Updated: Mar 14, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

3.2K
The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

10.4K
Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

7.4K

科学领域:

  • 神经科学是一个神经科学.
  • 神经退行性疾病 神经退行性疾病
  • 突触性可塑性 突触性可塑性

背景情况:

  • 肌缩侧面硬化 (ALS) 中的运动神经元 (MN) 脆弱性可能涉及激发/抑制 (E/I) 平衡的改变.
  • 在早期ALS发病过程中,抑制性突触的适应性变化的作用尚不清楚.

研究的目的:

  • 在早期的ALS中调查抑制性突触对MN的动态变化.
  • 探索抑制性突触对MN活动调节的恒常反应.
  • 评估调节抑制性突触元件对ALS疾病标志物的影响.

主要方法:

  • 来自SOD1G93A小鼠的MN的共聚焦显微镜.
  • 化学遗传工具 (PSAM,DREADD) 来改变MN的兴奋能力.
  • 一个E3酶结合体内 (GFE3) 降解Gephyrin和减少抑制性受体集群.

主要成果:

  • 在MN的抑制突触中观察到GlyR的下调和GABAR集群的上调.
  • 抑制性突触显示出平静反应,增加了MN活动加剧的集群.
  • GFE3治疗减少了抑制集群,增加了净MN活性,并减少了疾病标志物.
  • 综合活动增加和抑制降低并没有对疾病标志物产生净有益影响.

结论:

  • 抑制性突触在早期的ALS病变发生过程中具有动态作用,并表现出平稳调节.
  • 抑制抑制性突触增加了净MN活动,可能会影响疾病途径.
  • 调节抑制性突触元件为ALS提供了潜在的治疗途径.