利吉拉克托巴西勒斯 (Ligilactobacillus murinus) 通过恢复血清激素代谢来缓解饮食过度的行为
Yiwei Liao1, Jiaxin Chen2, Mengting Zeng2
1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Diseases (Xiangya Hospital), Changsha 410008, China; FuRong Laboratory, Changsha 410078, Hunan, China.
Food research international (Ottawa, Ont.)
|March 12, 2026
概括
肠道细菌Ligilactobacillus murinus可以通过恢复血清素 (5-HT) 水平和减少过度饮食行为来治疗过度饮食障碍 (OD). 这种益生菌通过影响肠-大脑信号传递,显示出对OD的治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 行为科学 行为科学
背景情况:
- 过度饮食障碍 (OD) 涉及没有补偿行为的过度饮食,与肠道失调和改变的血清素 (5-HT) 代谢有关.
- 影响OD神经化学变化的精确微生物机制尚不清楚.
- 现有的研究缺乏对肠道微生物群在OD病原发生中的作用的全面了解.
研究的目的:
- 研究肠道微生物群在过度饮食障碍 (OD) 的神经化学和行为方面的作用.
- 为了确定特定的微生物物种和机制,涉及到血清素 (5-HT) 调节障碍在OD.
- 评估Ligilactobacillus murinus (L. murinus) 作为OD治疗益生菌干预的治疗潜力.
主要方法:
- 建立了一个压力和食物限制小鼠模型,表现出OD表型和抑制的血清素 (5-HT) 水平.
- 利用抗生素治疗耗尽肠道微生物群,并评估其对暴饮暴食行为和5-HT代谢的影响.
- 采用16S rRNA基因测序来表征肠道疾病,并对L. murinus进行了针对性的益生菌干预.
- 研究了血清素 (5-HT) 合成和L. murinus衍生的-3-酸 (IAA) 在调解治疗效果中的作用.
主要成果:
- 肠道微生物群的枯竭加剧了暴饮暴食行为,并抑制了血清素 (5-HT) 途径.
- OD与肠道失调有关,特别是Ligilactobacillus丰度的减少,这与血清5-HT正相关.
- L. murinus的益生菌干预恢复了5-HT代谢,并显著改善了食感食物偏好,能量摄入量和食物冲动性.
- L. murinus的益处取决于5-HT合成,并通过IAA诱导的酸受体 (AHR) 信号通路的激活来介导.
结论:
- 肠道微生物群在调节宿主血清素 (5-HT) 代谢和过度饮食障碍 (OD) 中的过度饮食行为中发挥着关键作用.
- 利吉拉克托巴西勒斯 (L. murinus) 通过恢复5-HT水平和改善相关行为,证明了OD的显著治疗潜力.
- 这些发现突出了L. murinus作为一个有前途的下一代益生菌,通过IAA-AHR-5-HT途径针对肠-大脑轴进行OD治疗.
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