长期摄入素和肠道炎症:微生物变化,代谢机制和干预效应
Liangliang Zhu1, Yijia Chen1, Jiayang Jin2
1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Food research international (Ottawa, Ont.)
|March 12, 2026
概括
长期摄入素会通过改变肠道微生物和代谢物引起肠道失调和炎症. 特定的细菌,如Lactobacillus plantarum和Enterococcus faecalis可以降解素,减轻这些负面影响.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 素的消费很常见,但它对肠道健康的影响和潜在的机制尚不清楚.
- 肠道微生物群在维持肠道平衡和整体健康方面发挥着至关重要的作用.
研究的目的:
- 研究长期素消费对肠道微生物群组成和功能的影响.
- 阐明素影响肠道健康和炎症的机制.
- 为了确定参与素代谢及其对健康的影响的特定微生物和代谢物.
主要方法:
- 集成的人类队列数据与体外结肠模拟发酵.
- 利用基因组同质分析,机器学习预测和分子对接模拟.
- 使用细胞和动物模型 (与人类微生物群相关) 来评估微生物干预措施.
主要成果:
- 长期摄入素导致肠道失调,增加克莱布西拉和减少乳酸菌,与肠道炎症和代谢物调节失调相关.
- 已识别出素代谢物 (二甲素,酸,维拉特酸) 和利用素的微生物 (埃舍里希亚,克莱布西拉).
- 在大肠杆菌,K. aerogenes和E. faecalis中发现了酸脱酶同源蛋白,作为素代谢的潜在关键.
- 乳酸菌植物菌和菌菌 (Enterococcus faecalis) 在缓解素诱导的肠道炎症和通过降解素恢复肠道屏障功能方面表现出有效性.
结论:
- 长期的素消费会改变肠道微生物群和代谢物,诱导炎症和失生症.
- 特定的肠道细菌,Lactobacillus plantarum和Enterococcus faecalis,可以代谢素,为管理素诱导的肠道问题提供治疗策略.
- 这项研究提供了对素肠道效应的机制性见解,为经常食用的人保持肠道健康的策略提供信息.
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