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通过有针对性的选择性治疗来保持米索尔的疗效:来自小型反动物养殖场的长期实地证据
Juan Felipe de Jesús Torres-Acosta1, María Gabriela Mancilla-Montelongo2, Maria Christine Rizzon Cintra3
1Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
Veterinary parasitology, regional studies and reports
|March 12, 2026
概括
用levamisole (LEV) 进行的有针对性的选择性治疗 (TST) 在十年内证明了对胃肠道线虫 (GIN) 的持续杀虫剂 (AH) 疗效. 这一策略有助于保持药物的有效性,以长期控制牲畜中的寄生虫.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 动物健康管理 动物健康管理
- 它具有对虫的抵抗力.
背景情况:
- 胃肠道线虫 (GIN) 对牲畜健康和生产力构成重大威胁.
- 虫耐药性 (AR) 是一个日益关注的问题,需要可持续的治疗策略.
- 莱瓦米索尔 (LEV) 是一种广泛用于GIN控制的杀虫剂.
研究的目的:
- 根据有针对性的选择性治疗 (TST) 战略,评估勒瓦米索尔 (LEV) 的长期有效性.
- 在墨西哥和巴西的农场评估GIN对虫药物的耐药性.
- 为了证明TST如何保持甲虫 (AH) 疗效.
主要方法:
- 编制了十多年来来自三个农场 (两个大学,一个商业) 的历史便卵数减少测试 (FECRT) 数据.
- 分析了TST方案下的LEV疗效趋势.
- 在怀疑耐药性时,评估了LEV与其他杀虫剂结合的疗效.
主要成果:
- 一个农场在2024年略有下降,维持了超过二十年的LEV疗效率超过80%,在2024年略有下降.
- 另一家农场在2014-2020年期间显示持续高LEV疗效 (97%),随后下降 (2022年64%).
- 一个商业绵羊养殖场表现出了显著的稳定性,LEV疗效在十年内始终在91%至99%之间.
结论:
- 针对性选择性治疗 (TST) 方案似乎在较长时间内保持了勒瓦米索尔等杀虫剂的有效性.
- TST可以是一个有效的策略来减缓胃肠道线虫中抗甲虫药物耐药性的发展.
- 对于适应性管理策略来说,长期监测甲虫药的疗效至关重要.
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