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Updated: Mar 14, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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在ent-kaurane diterpenoids中发现和工程细菌P450s用于C-14氧化

Xiaoxu Lin1, Zhixi Xiao1, Xingwang Xu1

  • 1State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.

Nature communications
|March 13, 2026
PubMed
概括

一个新的计算策略成功地将关键的C-14基组引入了ent-Kaurane二烯酸 (ent-KTs),增强了它们的药用特性. 这一突破使得开发更强效的抗癌和抗炎药物成为可能.

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