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Cancer Survival Analysis

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一个全面的欧洲结肠直肠癌队列数据集.

Petr Holub1,2, Outi Törnwall3, Eva Garcia Alvarez4

  • 1BBMRI-ERIC, Neue Stiftingtalstrasse 2/B/6, 8010, Graz, Austria. petr.holub@bbmri-eric.eu.

Scientific data
|March 13, 2026
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概括

使用来自26个生物库的数据创建了一个大型的欧洲结直肠癌 (CRC) 队列. 本资源支持用于早期检测,预后和治疗CRC的生物标志物研究.

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科学领域:

  • 在瘤学瘤学.
  • 这是生物银行.
  • 数据科学数据科学数据科学

背景情况:

  • 结肠直肠癌 (CRC) 是一个重要的全球健康问题,推动了对强大的研究基础设施的需求.
  • 生物银行和生物分子资源欧洲研究基础设施 (BBMRI-ERIC) 启动了一个多国CRC队列,以整合患者数据.
  • 现有的生物库包含有价值的临床和分子数据,对于推进CRC研究至关重要.

研究的目的:

  • 建立一个全面的,欧洲范围的结直肠癌队列,用精心策划的临床数据.
  • 促进对生物标志物的研究,以便早期检测,预后和治疗CRC.
  • 整合先进的数据类型,包括组织病理学幻灯片和全基因组测序,用于新的研究应用.

主要方法:

  • 采用了回顾性多中心研究设计,收集了来自12个国家的26个生物库的数据.
  • 为数据收集和策划,定义了一个标准化的表型/临床数据模型.
  • 从10,780名CRC患者的个人数据被汇总到一个中央数据存储服务中.

主要成果:

  • 一个大规模的结肠直肠癌队列 (CRC-队列) 已成功建立了10780名患者.
  • 有结构化和精心策划的临床数据可用,支持各种研究途径.
  • 队列基础设施被扩展为组织病理学幻灯片和全基因组测序数据,使人工智能和EHDS的用例成为可能.

结论:

  • BBMRI-ERIC CRC-Cohort 代表了一个有价值的,大规模的资源,用于推进结直肠癌研究.
  • 实施FAIR和FAIR-Health原则可确保数据的可访问性和可重复使用性.
  • 这一倡议为CRC的精准医学和数字病理学未来研究提供了基础.