炼生理学中的肠神经系统:微生物群神经接口
Hui-Ling Chen1,2, Jia-Ting Huang1,2, Jian-Jun Guo3
1Center for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, China.
npj metabolic health and disease
|March 13, 2026
概括
肠道神经系统 (ENS) 在运动期间快速调节肠道功能,解释性能变化. 这个系统实时整合信号,与较慢的微生物群代谢物不同,并通过神经肠道表型影响运动适应.
科学领域:
- 运动生理学 运动生理学
- 神经胃肠病学 神经胃肠病学
- 微生物组研究的研究.
背景情况:
- 个体的运动反应有很大差异,其潜在的生物机制尚不清楚.
- 微生物群代谢物作用太慢,无法解释快速运动引起的生理变化.
- 需要一个快速的监管系统来解释实时的肠道和运动期间的性能适应.
研究的目的:
- 建议肠道神经系统 (ENS) 作为实时运动反应的关键调节器.
- 审查ENS在运动期间调节肠道功能和微生物群中的作用.
- 引入神经肠道现象,以解释运动耐受性的个体间变异性.
主要方法:
- 对ENS,肠道微生物群和运动生理学的现有研究进行文献综述.
- 对肠道运动,屏障功能和微生物生态的ENS调节证据的分析.
- 检查ENS与微生物群的交叉声和其向肌肉和大脑的信号通路的检查.
主要成果:
- 肠神经系统在运动期间实时整合机械,免疫和微生物信号.
- 肠神经系统在体力活动期间调节肠道运动,屏障功能和微生物生态.
- 肠道神经系统与肠道微生物群双向通信,并将信号传递给大脑和肌肉.
结论:
- 肠神经系统在快速,实时的生理适应运动方面发挥着关键作用.
- 神经肠道现象型为了解运动表现和适应能力的个体差异提供了一个框架.
- 针对ENS可能是优化运动耐受性和结果的新策略.
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