关节和其他骨折的BMD的预测值:用于更新FRAX的元分析
John A Kanis1,2, Eugene V McCloskey3,4, Helena Johansson3,5
1Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK. w.j.pontefract@sheffield.ac.uk.
概括
腿部部的低骨矿物质密度 (BMD) 是骨折风险的关键预测因素,特别是在男性和女性的部骨折中. 这种风险随着年龄的增长而变化,在老年人中降低.
科学领域:
- 骨质疏松症的研究研究.
- 骨健康流行病学 骨健康流行病学
背景情况:
- 用DXA测量大腿部的骨矿物质密度 (BMD) 对于评估骨折风险至关重要.
- 现有的风险评估工具,如FRAX®,可以通过更精确的数据进行更新.
研究的目的:
- 量化DXA测量的股骨部BMD与骨折风险之间的关联.
- 分析年龄,性别,测量后的时间和基线BMD如何影响骨折风险.
- 为了通知FRAX®骨折预测工具的更新.
主要方法:
- 在53个队伍中对307,205个人的初级数据进行了元分析.
- 随访持续时间平均为8.7年,总计超过260万人年.
- 用于评估骨骨折风险关联的普森回归模型,结果以风险梯度 (GR) 表示.
主要成果:
- 基线低骨质量或骨质疏松症存在于大多数关节骨折 (73-92%) 和主要骨质疏松性骨折 (MOF) 病例 (65-85%).
- 腿部部BMD强烈预测了男性和女性的关节骨折,风险梯度相似.
- 骨损伤和关节骨折风险之间的关联在年轻时更强,随着年龄的增长而减少.
结论:
- 腿部部骨质瘤是骨折的重要危险因素,特别是部骨折.
- 由于其他促成因素,关节骨折的BMD预测值随着年龄的增长而下降.
- BMD的国际验证支持其在骨折风险评估中的使用,考虑到年龄,性别和随访持续时间.
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