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一种基于结构的mRNA疫苗用于健康成年人中的尼帕病毒:一期试验

Aurélie Ploquin¹, Rosemarie D Mason¹, LaSonji A Holman¹

¹Vaccine Research Center, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nature medicine

|March 13, 2026

概括

一种新的尼帕病毒 (NiV) mRNA疫苗,mRNA-1215,在第一阶段试验中显示出良好的安全性和强大的免疫性. 这种有前途的尼帕病毒疫苗候选人为处于风险人群的进一步临床开发提供了保证.

科学领域:

病毒学病毒学
疫苗学疫苗学疫苗学
免疫学免疫学免疫学

背景情况:

尼帕病毒 (NiV) 是一种具有高度致病性的动物性病变性帕拉米克索病毒,具有流行病潜力.
目前,对于NiV感染,还没有获得许可的疫苗或治疗方法.
迫切需要采取有效的预防措施防止NiV疫情爆发.

研究的目的:

评估基于mRNA的尼帕病毒疫苗 (mRNA-1215) 的安全性,耐受性和免疫性.
在健康成年人中评估mRNA-1215的剂量升级效应.
确定mRNA-1215作为NiV预防候选疫苗的潜力.

主要方法:

在40名健康成年人中进行mRNA-1215的第1期,开放标签,剂量升级试验.
参与者在4周间隔内接受了两次肌肉注射mRNA-1215 (10,25,50,或100μg) 的剂量.
安全结果包括不良事件 (AE),实验室措施和严重的AE. 通过结合性和中和性抗体标位评估免疫性.

主要成果:

尼帕病毒疫苗mRNA-1215在所有剂量组中普遍耐受良好.
最常见的副作用是轻微的注射部位疼痛和不适;没有报告严重的副作用.
疫苗接种后观察到强大的结合和中和抗体反应,持续至少一年.

结论:

在最初的人类试验中,mRNA-1215表现出良好的安全性和强大的免疫性.
基于结构的,仿制的mRNA尼帕病毒疫苗是进一步临床开发的有希望的候选人.
对于那些面临尼帕病毒爆发风险的人群来说,持续发展至关重要.

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Viral Structure

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