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相关概念视频

Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

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Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
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Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

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Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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连续结晶平台用于结晶生物分子.

Siyu Pu1, Kunn Hadinoto2

  • 1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.

Advances in biochemical engineering/biotechnology
|March 13, 2026
PubMed
概括

连续结晶器在生物分子结晶方面提供了优越的性能,而不是批量方法. 本研究回顾了MSMPRC和PFC等先进的连续平台,突出了它们在下游加工方面的潜力.

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生物分子结晶的过程连续结晶的过程下游加工是下游加工.在MSMPR的结晶器.振荡流混结晶器 (OFBC) 是一种插入式流水结晶器 (PFC) 是一种蛋白质结晶的过程中的蛋白质结晶.污泥流结晶器 (SFC) 是一种

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科学领域:

  • 生物分子工程 生物分子工程
  • 化学工程是化学工程的重要组成部分.
  • 结晶技术 结晶技术 结晶技术

背景情况:

  • 批量结晶器是生物分子工业结晶的传统.
  • 连续结晶器正在出现,具有卓越的性能.
  • 生物分子结晶对于下游加工至关重要.

研究的目的:

  • 审查生物分子的创新型连续结晶器平台.
  • 讨论影响结晶运动和热力学的关键设计变量.
  • 为突出连续结晶作为染色学的替代品.

主要方法:

  • 关于连续结晶器设计的文献综述.
  • 讨论混合悬浮混合产品去除结晶器 (MSMPRC),插头流结晶器 (PFC),流结晶器 (SFC),振荡流混结晶器 (OFBC).
  • 包括膜和Couette-Taylor (CT) 结晶器等创新平台.

主要成果:

  • 连续结晶器 (MSMPRC,PFC,SFC,OFBC,膜,CT) 的详细说明.
  • 证明了用于球状蛋白质 (溶酶,胰岛素) 连续结晶的应用.
  • 分析了影响动力学 (RTD,混合) 和热力学的关键设计变量.

结论:

  • 连续结晶为生物分子下游加工提供了传统色谱的有希望的替代方案.
  • 先进的连续结晶器提供了增强的控制和效率.
  • 对设计变量的进一步调查可以优化生物分子结晶过程.