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Updated: Mar 14, 2026

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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通过蛋白质酶可切割的包含体标签访问难以处理的,酸化的内在无序蛋白质

Cat Hoang Vesely1,2, Stanislau Stanisheuski1,2, Edward Lien3

  • 1Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, USA.

Protein science : a publication of the Protein Society
|March 13, 2026
PubMed
概括

一个新的PINBody标签使化内在失序蛋白 (IDPs) 的稳定重组表达成为可能. 这种方法促进了对BAD和Tau等蛋白质的结构研究,这对于理解细胞亡和神经退行至关重要.

关键词:
这是NMR的NMR.塔乌塔乌 (Tau Tau) 是一个遗传密码扩张 扩张包括体标的身体标签.本质上是无序的蛋白质.酸化的方法是光化.

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