每周两次使用米卡丁作为在接受血造干细胞移植的儿童中进行抗真菌预防的药物
Syaza Ab Rahman1, Xin Yee Chiew1, Vida Jawin2
1Bone Marrow Transplantation Unit, Department of Pediatrics, Universiti Malaya Medical Centre, Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia.
Pediatric transplantation
|March 13, 2026
概括
每周两次的米卡金预防有效地预防了小儿血造干细胞移植患者的入侵性真菌感染. 这种安全的治疗方案为移植期间的抗真菌保护提供了一个可行的选择.
科学领域:
- 儿科血液瘤学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 接受血造干细胞移植 (HSCT) 的儿童面临侵入性真菌感染的高风险.
- 米卡金 (Micafungin) 是一种 echinocandin,具有广泛的抗真菌活性.
- 之前的研究表明,每天使用米卡金在儿科移植患者的预防中取得了成功.
研究的目的:
- 为了评估每周两次使用米卡芬金治疗方案的有效性和安全性,用于儿童HSCT接受者的抗真菌预防.
- 评估侵入性真菌感染的发生率和治疗耐受性.
主要方法:
- 在2018年5月至2024年2月期间,对100个连续的HSCT程序进行了回顾性分析.
- 从第0天开始,米卡金每周两次以3-5毫克/公斤的剂量进行,直到中性粒细胞移植,随后是可纳.
- 通过成像和培养来监测真菌感染状态;评估了疗效,安全性和耐受性.
主要成果:
- 在93名符合条件的患者 (95例移植) 中,没有被证实或可能发生的真菌感染.
- 18%的患者因发烧或可能的真菌感染 (例如食道炎) 需要转换为经验性抗真菌治疗.
- 没有患者因安全性或耐受性问题而停止服用米卡林.
结论:
- 每周两次静脉注射米卡芬金治疗方案是儿科高血压瘤治疗中抗真菌预防的安全有效策略.
- 这种剂量表为预防这种脆弱人群的真菌感染提供了有价值的替代方案.
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