血弹性查在血液疾病中揭示了其作为血液恶性瘤的诊断和预后生物标志物的潜力
Pasqualina Scala1,2, Anna Maria Della Corte1, Angela Bertolini1
1Department of Medicine, Surgery, and Dentistry, University of Salerno, Baronissi, Italy.
International journal of laboratory hematology
|March 13, 2026
概括
循环中的中性粒细胞弹性酶水平可以帮助区分血液性恶性瘤. 患者血弹性酶升高与生存率降低和治疗时间缩短有关,这表明其预后价值.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 中性粒细胞-细胞外陷 (NETs) 是由中性粒细胞释放的,其中含有脱凝的染色素和核蛋白.
- 中性粒细胞弹性酶是中性粒细胞中的关键蛋白酶,降解细胞外基质并具有促炎作用.
研究的目的:
- 研究血弹性酶水平在患有血液性恶性瘤的患者中的诊断和预后效用.
- 评估血弹性酶水平与临床结果之间的相关性.
主要方法:
- 从111名患有血液性恶性瘤的患者和42名健康的捐赠者收集了血样本.
- 血弹性酶水平使用ELISA量化.
- 患者根据血弹性酶水平 (切断值300 ng/mL) 进行了分层,以比较临床结果.
主要成果:
- 血弹性酶水平在骨髓质疏松症候群和慢性淋巴细胞白血病中降低.
- 在急性髓性白血病 (AML) 和非霍奇金淋巴瘤 (NHL) 中观察到血弹性酶的升高,具有显著的诊断准确性 (AML AUC=0.78,NHL AUC=0.75).
- 较高的血弹性酶水平与降低的整体存活率,无进展的存活率和较短的治疗时间有关.
结论:
- 循环等离子弹性酶可以帮助对血液恶性瘤的差异诊断.
- 血弹性酶作为预后生物标志物,用于血液恶性瘤的疾病进展和治疗反应.
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