通过开放和封闭标签的反条件化可以减少nocebo效应吗?
Simone Meijer1,2,3, Andrea W M Evers1,2,3,4, Kaya J Peerdeman1,2,3
1Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.
European journal of pain (London, England)
|March 13, 2026
概括
开放标签的反条件有效地减少了对疼痛的nocebo效应,即使没有欺骗. 这种基于学习的方法提供了一个有希望的,伦理的策略来管理痛苦和其他条件受到负面期望的影响.
科学领域:
- 心理学 心理学 心理学
- 疼痛研究 疼痛研究
- 行为医学是一种行为医学.
背景情况:
- 诺塞博效应会对疼痛等身体症状产生负面影响.
- 减少nocebo效应的策略至关重要.
- 开放标签的反条件表现有希望,但需要与封闭标签的方法进行比较.
研究的目的:
- 为了研究开放式的反条件化是否减少了对压力疼痛的nocebo效应.
- 为了比较开放标签的反条件与封闭标签的反条件和灭绝.
- 评估这些干预措施中安慰剂预期的作用.
主要方法:
- 随机对照试验与66名健康女性参与者.
- 调查了开放标签的反条件,封闭标签的反条件和灭绝.
- 对压力疼痛有条件的nocebo效应的测量减少.
主要成果:
- 开放标签的反条件显著降低了nocebo效应 (d=1.13).
- 开放标签的反条件比灭绝 (d=0.85) 更有效,并诱导了安慰剂效应.
- 封闭标签的反条件也减少了nocebo效应,特别是在响应者中.
结论:
- 开放式的反条件化是一种高效的,非欺骗性的方法,用于调节对疼痛的nocebo效应.
- 这种方法有望为包括慢性疼痛在内的各种患者群体开发伦理,基于学习的治疗方法.
- 结果支持使用开放标签的反条件作为欺骗策略的替代方案.
相关概念视频
Classical Conditioning in Daily Life
2.6K
Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
2.6K
Blind Procedures
13.8K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.8K
Operant Conditioning Intervention
601
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
In operant conditioning, behaviors that are...
601
The Placebo Effect
7.0K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
7.0K
Blinding
4.0K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
4.0K
Conditioned Taste Aversion
1.4K
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
A notable characteristic of conditioned taste aversion is that it often requires only a single...
1.4K


