结核病后肺部疾病的气流阻塞:5年前性队列研究
Zi Kang Sheng1, Wen Li Cao2, Hong Ling Chu3
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital; Chronic Airway Diseases Research Center, Peking University Health Science Center; Beijing 100191, China.
结核病后肺部疾病 (PTLD) 即使在年轻的非吸烟者中也会导致气流阻塞. 长期监测肺功能对于结核病幸存者来说至关重要,以检测和管理TB-COPD等疾病.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 结核病后肺部疾病 (PTLD) 包括结核病相关的慢性阻塞性肺部疾病 (TB-COPD) 等疾病.
- 在PTLD中,空气流阻塞的长期临床轨迹和风险因素尚未完全理解.
研究的目的:
- 在为活跃肺结核治疗的患者中,评估五年来肺功能的纵向变化.
- 在这个群体中确定空气流阻塞的预测因素.
主要方法:
- 一组患有活跃肺结核的患者被纵向跟踪.
- 评估包括肺功能测试和胸部CT扫描在治疗结束时和治疗后五年.
主要成果:
- 空气流阻塞从基线时的13.2%增加到5年随访时的17.0%.
- 在五年内观察到平均FEV1/FVC比率的显著下降.
- 胸部CT检测结果与结核病-COPD一致,包括空气陷,即使在年轻的,非吸烟者.
结论:
- 空气流阻塞是肺结核的一个显著的长期并发症.
- 阻塞的发展和持续,特别是结核病-COPD表型,凸显了需要扩大后续的需要.
- 建议对结核病幸存者进行例行肺功能评估.
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