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高通量测序用于结核病诊断和检测抗菌素耐药性:进展,挑战和未来前景

Lu Lu Zhang¹, Jun Ping Peng¹

¹NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, China;Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, China;Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, China.

Biomedical and environmental sciences : BES

|March 13, 2026

概括

高通量测序 (HTS) 提供了快速结核病 (TB) 诊断和抗菌素耐药性 (AMR) 检测. 本综述探讨了HTS应用,挑战和全球结核病控制的未来方向.

科学领域:

微生物学微生物学
基因组学就是基因组学.
公共卫生公共卫生

背景情况:

结核病 (TB) 仍然是全球主要的健康威胁.
传统的结核病诊断速度缓慢,缺乏全面的抗菌素耐药性 (AMR) 分析.
高通量测序 (HTS) 在病原体研究中提供了更好的速度和准确性.

研究的目的:

审查HTS在结核病诊断和AMR检测中的应用.
探索HTS用于流行病学研究,药物开发和疫苗研究.
确定全球结核病控制中HTS的局限性和未来方向.

主要方法:

对结核病中HTS应用的当前文献进行系统审查.
对结核病研究的各种测序策略和平台的分析.
检查技术和生物信息学挑战.

主要成果:

通过HTS,可以快速识别病原体,并进行全面的AMR分析.
基因组多样性和AMR的分子机制可以使用HTS来阐明.
支持流行病学研究,新药发现和疫苗开发.

结论:

HTS技术正在彻底改变结核病诊断和AMR检测.
克服技术和生物信息学挑战对于HTS集成至关重要.
未来的努力应集中在将HTS整合到全球结核病控制战略中.

关键词:

抗微生物耐药性抗微生物耐药性高通量测序的高通量测序结核病是一种疾病.

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