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相关实验视频

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扩散MRI采样方案偏差扩散指标和曲谱学.

Ivanei Bramati1,2, Diego Szczupak2,3, Marina Carneiro Monteiro1

  • 1Department of Brain Connectivity and Plasticity, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.

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概括

不同的扩散MRI采样方案在白质分析中产生系统偏差. 需要协调方法来结合来自不同协议的数据,以进行准确的脑结构研究.

关键词:
异常的白物质束束是异常的.身体质体的发育不良.扩散磁力共振成像 (MRI) 扩散扩散指标的扩散指标.统一化和化 统一化和化路径学 路径学 路径学 路径学 路径学

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科学领域:

  • 神经成像是一种神经成像.
  • 扩散式核磁共振成像 (MRI)
  • 白物质的解剖学 白物质的解剖学

背景情况:

  • 扩散MRI对于研究白质结构至关重要.
  • 流体图和扩散指标可以受到不同的采样方案的影响.
  • 了解这些差异对于可靠的数据解释至关重要.

研究的目的:

  • 评估四种常见协议的扩散MRI指标和通道图学的系统差异:单HARDI,西门子多 (SMS),DSI和HCP多 (HCPms).
  • 评估这些差异在健康的成人和患有体发育不良症 (CCD) 的人群中.

主要方法:

  • 在3T扫描仪上获取数据,并以统一的方式处理.
  • 提取的分数异构性 (FA),平均扩散性 (MD),有效对比比 (eCNR) 和方向分散.
  • 在特定白质区域 (CC,CR,CSO,AC,PC) 和CCD特定捆绑 (Probst,sigmoid) 中测量了管道体积和精简计数.

主要成果:

  • FA和MD在各方案之间显示了中等的相关性,但匹配的平均值并不常见.
  • eCNR和分散具有有限的跨方案相关性,Sms/HCPms和HARDI/DSI/HCPms之间有一些相似之处.
  • 对于CC (控制) 和CCD捆绑的SMS,DSI和HCPms之间,通道体积相关;DSI和HCPms显示一致的体积.
  • 在CR中,SMS的数量与DSI/HCPms一致,但在CC和CCDROI中较低;HARDI在CC,CR和CCDROI中产生了更高的数量.
  • 跨方案的AC和PC通道指标一致,但相关性不同.

结论:

  • 四个扩散采样方案显示了voxel-wise指标和曲谱学结果的系统差异.
  • 调查结果为整合或对比跨方案数据的努力提供了信息.
  • 未来的研究应该探索协调方法,以减少偏见,并使跨多种协议进行聚合分析.