在2型糖尿病中,身体圆度指数与左心室扩张功能障碍之间的非线性关联
Yanan Li1,2, Zhiguo Wang1,2, Yifei Ma1,2
1Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in endocrinology
|March 13, 2026
概括
身体圆度指数 (BRI) 与2型糖尿病 (T2DM) 患者的左心室扩张性功能障碍 (LVDD) 的风险更高有关. 这种关联是非线性的,在BRI = 8.1.1时观察到值效应.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 左心室扩张功能障碍 (LVDD) 是2型糖尿病 (T2DM) 的常见并发症.
- 内脏脂肪,通常反映在身体圆度指数 (BRI),与LVDD相关.
- 在T2DM患者中,BRI和LVDD之间的确切关系需要进一步调查.
研究的目的:
- 在T2DM患者中调查BRI和LVDD风险之间的关联.
- 探索BRI对LVDD的潜在非线性关系和值效应.
- 在T2DM中确定BRI作为LVDD风险分层的潜在生物标志物.
主要方法:
- 一项涉及1,317名T2DM患者的横截面研究.
- 采用了多变量逻辑回归和通用添加模型 (GAM).
- 使用两步递归方法评估非线性关联和值效应.
主要成果:
- 在T2DM中,在BRI和LVDD风险之间发现了显著的非线性关联.
- 每增加1个单位的BRI与30%更高的LVDD风险相关 (OR: 1.30,95%CI: 1.10-1.60).
- 在BRI=8.1时确定了一个转折点,在这个门以下有更强的关联.
结论:
- 在T2DM中,BRI证明了与LVDD风险的非线性关联,在BRI = 8.1.1时具有值效应.
- 在糖尿病病患者中,BRI和LVDD之间的关联更加明显.
- BRI可以作为一种有价值的工具来识别LVDD风险较高的T2DM患者.
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