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在接受TURP的患者中,灌液温度调节凝血和内皮生物标志物

Min Gu¹, Yanqiu Xu²

¹Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, China.

Journal of medical biochemistry

|March 13, 2026

概括

灌液的温度会影响前列腺手术期间的出血. 低温会损害凝血和血小板功能,而预热可以维持血静并减少并发症.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
外科手术静血静血是什么
凝血生理学凝血生理学

背景情况:

灌液的温度是一个关键的,往往被忽视的因素,在经尿道切除前列腺 (TURP).
虽然低温的临床影响已知,但其对凝血和内皮标记物的特定生化影响需要进一步研究.

研究的目的:

调查灌液温度在 TURP 期间对凝血和内皮标记物的生化影响.
为了比较与不同灌液温度相关的静血稳定性和不良事件.

主要方法:

为良性前列腺增生而接受 TURP 的 90 名患者被随机分为三个灌液温度组:低温 (24-26 °C),轻度低温 (28-35 °C) 和预热 (36-37 °C).
外周血液是在手术前和手术后6小时收集的.
评估了凝血指数 (前列血时间,激活的部分血栓形成时间,血小板计数,血小板聚合率) 和内甲蛋白-1水平.

主要成果:

与预热相比,低温显著延长了激活的部分血栓形成时间 (APTT),降低了血小板计数 (PLT) 和血小板聚合率 (Pagt) (P < 0.05).
在不同组中,前血时间 (PT) 保持不变.
在低温和预热组中,内甲素-1 (ET-1) 水平降低,预热组的降低最为显著.
预热组显示凝血稳定性得到保护,相比低温 (33.3%) 和轻度低温 (23.3%) 组 (P = 0.038) 显著减少不良事件 (6.7%).

结论:

在TURP期间的低温灌通过延长APTT和减少血小板功能来损害凝血.
将灌液预热至36-37°C,可以维持静血平衡,并与较少的不良事件有关.
优化灌流体温度对于在TURP手术中管理术后静血至关重要.

关键词:

激活的部分血栓形成时间 (APTT)凝血生物标志物凝血生物标志物末端蛋白-1-1的使用.低温症低温症是一个血小板功能血小板功能

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