微生物组 - 菌毒素相互作用和益生菌策略:对肠道健康和癌症的影响
Alice N Mafe1, Dietrich Büsselberg2
1Faculty of Sciences, Department of Biological Sciences, Taraba State University, Jalingo, Nigeria.
Frontiers in nutrition
|March 13, 2026
概括
菌毒素破坏肠道健康,促进癌症. 肠道微生物组可以排毒这些毒素,益生菌提供了一种有希望的策略,以减轻菌毒素引起的损害.
科学领域:
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 菌毒素是常见的食物污染物,对肠道健康有不利影响.
- 肠道微生物群与真菌毒素的相互作用影响排毒,免疫力和屏障功能.
- 对这些相互作用的机制理解,特别是关于癌症信号的理解,是不完整的.
研究的目的:
- 审查关于肠道微生物群介导的菌毒素生物转化最近的机械研究 (2016-2025年).
- 探索酶性解毒途径和益生菌干预措施,以减轻菌毒素引起的损害.
- 为了解肠道健康和癌症中的微生物组-菌毒素相互作用提供一个框架.
主要方法:
- 机械学研究的叙述性综述,重点是肠道微生物群对菌毒素生物转化.
- 对酶性解毒途径 (去氧化酶,乳酶,减少酶) 的分析.
- 评估益生菌策略,包括毒素结合,竞争性排斥和免疫调节.
主要成果:
- 微生物酶对菌毒素生物转化有显著的贡献.
- 益生菌可以增强肠道屏障功能,恢复微生物平衡,减少炎症.
- 菌毒素诱导的失生症会影响短链脂肪酸的产生和与癌症相关的信号通路 (NF-κB,STAT3,IL-6).
结论:
- 肠道微生物群在缓解菌毒素毒性方面发挥着至关重要的作用.
- 益生菌干预措施显示出降低毒素相关的肠道和癌症风险的潜力.
- 需要进一步的研究来阐明菌株特异性解毒和优化益生菌策略.
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