肝脑病的肠道微生物群:3PM指导的三层健康战略
Jing Chen1,2, Mingliao Niu3, Longjiang Zhang3
1Henan University of Chinese Medicine, Zhengzhou, 450001 China.
The EPMA journal
|March 13, 2026
概括
肠道微生物群调制可以预测,预防和治疗肝脏脑病变 (HE). 改变生活方式是通过改善肠道健康和减少神经毒素来管理HE的关键.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 神经学 神经学
- 微生物组研究 微生物组研究
背景情况:
- 肝脑病变 (HE) 是肝硬化严重并发症,死亡率和复发率高.
- 目前的HE治疗缺乏个性化,导致高医疗费用和低于最佳的结果.
- 肠道微生物群失生症越来越被认为是HE发展的先驱.
研究的目的:
- 审查使用肠道微生物群干预措施治疗HE的策略.
- 探索预测,预防和个性化医学 (PPPM/3PM) 在高等卫生管理中的应用.
- 突出生活方式修改在调节肠道微生物群中的作用,以预防和治疗高血压.
主要方法:
- 关于肠道微生物群和肝脏脑病的研究的文献综述.
- 分析肠道微生物群影响HE病变的机制.
- 讨论针对个性化的HE治疗的PPPM/3PM方法.
主要成果:
- 肠道微生物群失调是HE发病前的一个重要因素.
- 调节肠道微生物群可以保护屏障功能,减少神经毒素,并改善神经递质功能.
- 个性化肠道微生物群干预措施对HE预测,预防和治疗有希望.
结论:
- 肠道微生物群作为个性化生物标志物用于HE风险预测.
- 准肠道微生物群为HE提供了一个个性化的治疗策略.
- 改变生活方式对于调节肠道微生物群和预防/治疗HE至关重要,也是具有成本效益的干预措施.
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