焦虑和抑郁症中的肠道微生物群:病原和治疗方法
Stefano Bibbò1, Salvatore Fusco2, Gianluca Ianiro1
1CEMAD Digestive Disease Center, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.
Frontiers in gastroenterology (Lausanne, Switzerland)
|March 13, 2026
概括
肠-大脑轴在抑郁和焦虑中起着至关重要的作用. 通过益生菌或便移植调节肠道微生物群,显示出作为这些情绪障碍的个性化辅助治疗的希望.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 抑郁症和焦虑症是显著的临床挑战,对于一些患者来说,治疗反应有限.
- 新兴研究强调了肠-大脑轴和肠道微生物群在情绪调节中的作用.
- 肠道微生物通过氨基酸代谢,短链脂肪酸,迷走神经和免疫信号影响大脑功能.
研究的目的:
- 探索肠道微生物群调节作为抑郁症和焦虑症个性化治疗策略的潜力.
- 审查支持肠-大脑轴在情绪障碍中的证据.
- 评估益生菌,共生菌和便微生物群移植在治疗这些疾病中的有效性.
主要方法:
- 对肠-大脑轴和情绪障碍的临床前和临床研究的综述.
- 分析肠道微生物与大脑相互作用的机制.
- 检查涉及肠道微生物群转移和调制疗法的研究.
主要成果:
- 肠道微生物群转移实验证实了肠道微生物在情绪和焦虑障碍中的起因作用.
- 在患有焦虑和抑郁症的患者中,经常观察到失调症.
- 益生菌,共生菌和便微生物群移植显示出改善临床症状的潜力,尽管移植的证据有限.
结论:
- 肠道微生物群调节剂代表了抗抑郁药治疗的有前途的辅助疗法.
- 准肠道微生物群为焦虑和抑郁症提供了新的,个性化的治疗途径.
- 进一步发展制药和营养药品战略是有必要的.
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