结肠直肠癌查的未来:从一个尺寸适合所有人到量身定制
Tim Kortlever1, Manon van der Vlugt1, Evelien Dekker1
1Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Frontiers in gastroenterology (Lausanne, Switzerland)
|March 13, 2026
概括
基于风险的模型可以通过比便免疫化学测试 (FIT) 更准确地识别高风险个体来改善结直肠癌 (CRC) 查. 这些先进的策略旨在优化CRC检测并降低死亡率.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 生物标志物研究 生物标志物研究
背景情况:
- 结肠直肠癌 (CRC) 查降低了死亡率,但如结肠镜检查等目前的方法成本昂贵,参与率低.
- 便免疫化学测试 (FIT) 是非侵入性和廉价的,但患有晚期瘤的低敏感性和高错误阳性率,导致不必要的程序.
研究的目的:
- 审查基于风险的结直肠癌查模型的发展.
- 讨论将这些新型风险模型应用于现有CRC查计划中的挑战.
主要方法:
- 对CRC查风险模型的文献综述.
- 分析包括多个风险因素和生物标志物的横截面和纵向风险模型.
主要成果:
- 风险模型比目前的CRC选方法提供了潜在的改进.
- 现有的风险模型在公共卫生计划中面临广泛实施的障碍.
结论:
- 需要新的基于风险的策略来提高结直肠癌 (CRC) 查的有效性和效率.
- 克服实施障碍对于成功将先进的风险模型集成到基于人口的CRC查计划中至关重要.
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