同型氨酸是患有心肌炎的儿童排泄分数减少的危险因素:单中心研究
Chengjun Zhang1, Xiuwen Ren2, Yufan Xu2
1Department of Pediatric, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Frontiers in pediatrics
|March 13, 2026
概括
高水平的同类半氨酸 (HCY) 与心肌炎儿童的排泄分数 (EF) 降低有关. 这种风险在男性和超重儿科患者中更高,表明HCY是潜在的生物标志物.
科学领域:
- 心脏病学 心脏病学
- 儿科医学 儿科医学
- 生物化学 生物化学
背景情况:
- 同型半氨酸 (HCY) 和射出分数 (EF) 之间的关联已在患有心血管疾病的成年人中确立.
- 然而,诊断为心肌炎的儿科患者中HCY和EF之间的关系尚不清楚.
研究的目的:
- 调查患有心肌炎的儿科患者的同类氨酸水平和射出分数之间的潜在关系.
- 确定HCY作为在这个特定的儿科群体中降低EF的可能危险因素.
主要方法:
- 进行了一项涉及164名儿科心肌炎患者 (1-18岁) 的横截面研究.
- 评估了用3.0T心脏磁共振 (CMR) 测量的同类氨酸水平和射出分数.
- 统计分析包括t测试,二进制逻辑回归和受限立方线 (RCS) 建模,并根据年龄,性别和BMI进行子组分析.
主要成果:
- 31%的儿科患者表现出减少的喷射分数 (EF <55%).
- 较高的同类半氨酸水平与EF降低的风险有显著的积极关联 (OR = 1.033,P = 0.034).
- 亚组分析显示,男性和BMI≥24kg/m2的患者中高HCY和降低EF之间的相关性更强.
结论:
- 升高的同类半氨酸水平代表了小儿心肌炎患者中排泄分数减少的显著风险因素.
- 这种联系在男性儿科患者和超重患者中尤为明显.
- 这些发现凸显了HCY作为评估儿科心肌炎心脏功能生物标志物的潜在作用.
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