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童年口吃中的语音网络:计划和运动循环的功能连接的差异
Fiona Höbler1,2, Yanni Liu1, Adriene M Beltz1
1Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Neurobiology of language (Cambridge, Mass.)
|March 13, 2026
概括
儿童发育性口吃涉及到语言网络中的大脑连接的改变. 这项研究揭示了自言的孩子和不自言的孩子之间基底 - 甲状腺 - 皮质电路的差异.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 语音科学 语言科学
背景情况:
- 发育性口吃是一种神经发育状况,与基底 - 甲状腺 - 皮质 (BGTC) 电路异常有关.
- 这些电路对于语音的规划和执行至关重要.
研究的目的:
- 研究的儿童 (CWS) 与不的儿童 (CNS) 之间的语音规划和运动回路的功能连接障碍.
- 利用休息状态功能磁共振成像 (rsfMRI) 的个人特定功能连接地图.
主要方法:
- 从73个中枢神经系统和74个中枢神经系统 (年龄在3-10岁之间) 获取了rsfMRI数据.
- 提取了12个在语音电机网络中感兴趣的区域.
- 评估功能连接性使用确认分组组组代多重模型估计 (CS-GIMME) 对组,子组和个人层面进行评估.
主要成果:
- 亚组分析显示,CWS中的规划和机动环节的连接发生了变化,与CNS相比,网络内连接性减少.
- 在CWS中观察到左后下额头和左腹侧丘脑之间独特的连接性.
- 在CWS中,左腹侧丘脑和右腹前运动皮层的中心性增加.
结论:
- 网络内部连接的显著差异表明,CWS中的BGTC电路在早期发展过程中发生了变化.
- 这些发现表明神经网络在发育性口吃儿童的编程,规划和语音运动序列的时间方面的低效率.
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