马什和肝脏抗纤维素药物的竞赛
1Ochre Bio, Oxford, United Kingdom.
Frontiers in gastroenterology (Lausanne, Switzerland)
|March 13, 2026
概括
新的代谢疗法为治疗代谢功能障碍相关的脂肪肝炎 (MASH) 肝纤维化提供了希望. 新兴的治疗方法针对肝脂肪和纤维化,有可能改善慢性肝病患者的治疗结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 纤维化研究 纤维化研究
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 和慢性肝病导致渐进性纤维化和肝硬化,是导致死亡的主要原因.
- 过去的抗纤维菌药物开发面临着挑战,但最近的代谢疗法进展为治疗提供了新的途径.
研究的目的:
- 总结针对MASH和其他慢性肝病的新兴抗纤维菌疗法.
- 讨论代谢疗法的潜力,包括直接和间接作用的药物.
- 探索未来的治疗组合,患者分层,以及纤维化逆转的最终目标.
主要方法:
- 对抗纤维菌剂的当前文献的审查,重点是代谢疗法.
- 分析新兴药物类别,包括GLP-1类似物,THRβ激活剂和FGF21类似物.
- 讨论非代谢性抗纤维素药物和未来研究方向.
主要成果:
- 代谢疗法,如GLP-1类似物,THRβ激活剂和FGF21类似物,在减少肝脂肪和潜在的纤维化方面表现有前途.
- 间接作用的药物促进体重减轻以减少肝脏脂肪,而直接作用的药物向肝脏中的特定途径.
- 非代谢性抗纤维素药物的开发进展比代谢疗法慢.
结论:
- 新兴的代谢疗法在治疗与MASH相关的肝纤维化方面取得了重大进展.
- 未来的策略可能包括结合代谢和非代谢药物,以及患者分层,以优化治疗结果.
- 主要的治疗目标可能需要扩大,不仅仅是纤维化逆转,包括更广泛的患者益处.
相关概念视频
Ultrasound II: Endoscopic Ultrasound and FibroScan
983
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
983
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
309
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
309
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
247
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
247
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
615
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
615
Hepatic Drug Clearance: Effect of Protein Binding
648
Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
648
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
531
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
531


