评估IBD的肠道准备耐受性:曼尼托和PEG-ASC的第三阶段后期比较
Gian Eugenio Tontini1,2, Alessandro Rimondi1,3, Flavio Caprioli1,2
1Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy.
Frontiers in gastroenterology (Lausanne, Switzerland)
|March 13, 2026
概括
口服曼尼托尔 (OM) 为炎症性肠病 (IBD) 患者的结肠镜检查提供了耐受性良好,有效的肠道制备. 与标准方法相比,这种甜味的药可以提高患者的满意度和坚持性.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 患者护理 患者护理
背景情况:
- 肠道准备进行结肠镜检查具有挑战性,特别是对于炎症性肠病 (IBD) 患者.
- 口服曼尼托 (OM) 是一种超低体积的透性药,具有甜味,可以提高耐受性.
研究的目的:
- 为了比较同一天的口服曼尼托尔 (OM) 与标准分剂量聚乙烯甘醇加酸盐 (PEG-ASC) 用于IBD患者的肠道准备.
- 评估肠道清洗的疗效,内镜检查结果,安全性和患者满意度.
主要方法:
- 对第三期,多中心,随机,内镜盲目的SATISFACTION试验的后期分析.
- 55名IBD患者被分为OM (n=24) 和PEG-ASC (n=31) 组.
- 评估了肠道准备的质量,安全性和患者报告的结果.
主要成果:
- OM表现出优越的耐受性:使用方便性 (88%对71%),口味满意度 (75%对6%) 和愿意重复使用 (96%对71%).
- OM显著减少了摄入时间 (32分比107分钟) 和疏散时间 (57分比91分钟).
- 在OM和PEG-ASC之间,有效性,清洁质量和安全性是可比的.
结论:
- 同一天的OM准备可以提高IBD患者接受结肠镜检查的患者的患者满意度和坚持.
- 对IBD患者来说,OM提供了一种安全有效的替代标准肠道准备方案.
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
1.1K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.1K
Drugs for Treatment of Diarrhea-Predominant IBS
832
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
832
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
998
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
998
Irritable Bowel Syndrome III: Medical and Nursing Management
959
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
959
Drugs for Treatment of Ulcerative Colitis in IBD
589
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
589
Lower GI Series: Barium Enema
2.2K
A Barium Enema, or a lower GI series, is a specialized radiographic examination designed to visualize the lower gastrointestinal tract, specifically the colon and rectum. This procedure is instrumental in diagnosing various conditions such as colorectal cancer, polyps, diverticulosis, and inflammatory bowel disease.
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
2.2K


