通过使用自动化选择性驱动算法进行多电极穿皮脊髓刺激来改善肌肉招募
Mouhamed Zorkot, Solaiman Shokur, Riccardo Carpineto1
1Translational Neural Engineering (TNE) Lab, Neuro-X Institute, EPFL, Geneva, Switzerland.
APL bioengineering
|March 13, 2026
概括
自动化算法和在线脊髓反射检测提高了脊髓损伤 (SCI) 患者个性化步行康复的穿皮脊髓刺激 (tSCS) 选择性.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复科学 康复科学 康复科学
背景情况:
- 脊髓损伤 (SCI) 显著影响运动功能和生活质量.
- 穿皮脊髓刺激 (tSCS) 是一种用于恢复运动功能的非侵入性神经调节技术.
- 目前的 tSCS 方法,特别是单个电极配置,具有有限的肌肉招募选择性,阻碍了临床应用.
研究的目的:
- 为了提高多电极 tSCS 配置的选择性.
- 实施在线脊柱反射检测和自动算法,以实现个性化的刺激参数.
- 为了实现目标肌肉群的选择性激活,以改善步行康复.
主要方法:
- 开发了一种自动化协议,在线检测脊髓反射和分析肌肉反应.
- 在14名健康参与者身上测试了两种多电极配置 (中线和双边).
- 采用了两种算法:基于排名的方法 (RBA) 和选择性驱动的方法 (SDA) 来优化电极位置和刺激幅度.
主要成果:
- 在多电极SCS中,RBA和SDA都增强了 rostrocaudal和ipsilateral选择性.
- 通过量化分级的EMG反应,SDA通过量化分级的EMG反应,证明了对选择性肌肉组招募的卓越适应性.
- 结果挑战了关于STSC选择性的假设,揭示了肌肉招募模式的个体间变异性.
结论:
- 自动化算法和在线反射检测对于优化 tSCS,减少手动校准至关重要.
- 开发的方法考虑了跨主体的变化,使得更有针对性的神经调节.
- 这种方法为SCI和其他神经疾病患者提供了个性化步行康复.
相关概念视频
01:20Motor Unit Stimulation
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
01:22Muscle Stimulation Frequency
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...