多双和乳腺癌:证据,机制和风险管理
Shuaiyang Zhang1, Hongliang Cao2, Runzhou Lian1
1Department of Breast Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China.
Frontiers in cell and developmental biology
|March 13, 2026
概括
多双 (PCB) 通过代谢,氧化和表观遗传变化,积极驱动乳腺癌. 本次审查提出了风险管理和精确预防策略的框架.
科学领域:
- 环境毒理学环境毒理学
- 癌症生物学 癌症生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 流行病学数据显示,在将多二 (PCB) 与乳腺癌联系方面存在不一致.
- PCB 是一种持久性有机污染物,具有广泛的环境污染.
- 了解PCB诱导的乳腺癌的精确机制对于公共卫生至关重要.
研究的目的:
- 综合多学科证据关于PCB在乳腺癌中的作用.
- 通过代谢-氧化-表观遗传轴,将PCB描述为瘤发生的活性驱动因素.
- 为PCB暴露和乳腺癌提出一个综合风险管理框架.
主要方法:
- 对PCB和乳腺癌的现有流行病学,机械学和毒理学研究的审查.
- 对代谢途径,氧化应激标志物和表观遗传修饰的分析.
- 检查受体交叉 (亚里尔碳化合物受体[AhR]和雌激素受体[ER]) 和酶活性 (十-十一转位[TET]).
主要成果:
- PCB 在脂肪组织中积累,导致长期的毒性.
- AhR / ER交叉声会诱导线粒体功能障碍和氧化应激,改变表观遗传模式.
- 特定的PCB原体可能会影响不同的乳腺癌亚型和治疗耐药性.
结论:
- PCB 不仅仅是暴露相关物质,而且是乳腺癌的积极驱动因素.
- 代谢-氧化-表观遗传轴是PCB诱导的瘤发生的基础.
- 建议为与PCB相关的乳腺癌预防提供环境修复和临床干预的综合框架.
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