相关实验视频

Updated: Mar 14, 2026

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

机器学习衍生的AS和AIS分数利用BCAA代谢和IL4I1活性用于预后和ccRCC中的量身定制治疗

Kang Qiang Weng¹, Xin Li¹, Xiao Bao Chen¹

¹Department of Urology, Fujian Medical University Union Hospital, Fuzhou, China.

Frontiers in cell and developmental biology

|March 13, 2026

概括

分支链氨基酸代谢影响清细胞细胞癌 (ccRCC) 的进展. 新的分数 (AS和AIS) 有助于个性化治疗,而IL4I1则成为潜在的治疗目标.

科学领域:

在瘤学瘤学.
代谢学代谢学代谢学
生物信息学是一种生物信息学.

背景情况:

细胞癌 (RCC),特别是清细胞ccRCC (ccRCC),是一个重大的全球健康挑战,晚期预后不佳.
晚期cccRCC的5年生存率仍然非常低,这强调了需要改进治疗策略的必要性.

研究的目的:

研究分支链氨基酸代谢在ccRCC进展和治疗反应中的作用.
开发ccRCC中患者分层和个性化治疗的新型预测得分.
探索在ccRCC病变发生过程中IL4I1的功能和分子相互作用.

主要方法:

使用单细胞数据分析和机器学习算法 (10种类型) 来创建氨基酸签名 (AS) 评分.
应用主要成分分析来开发氨基酸个性化签名 (AIS) 评分,以提供个性化治疗指导.
空间转录组学和单细胞多组学被用来研究IL4I1相互作用和调节机制.

主要成果:

分支链氨基酸代谢显著影响ccRCC的进展和治疗结果.
AS评分有效地根据临床特征和药物敏感性区分ccRCC患者亚组.
AIS评分在指导二线和免疫疗法方面具有实用性,特别是在向治疗失败时.
升高的IL4I1表达通过增强分支链氨基酸降解来促进ccRCC的生长和转移.
VHL突变可能通过Hif-1a和SFMBT1上调IL4I1表达,加剧瘤进展.

结论:

分支链氨基酸代谢和IL4I1是ccRCC进展的关键因素.
AS分类和AIS分数为个性化的ccRCC治疗策略提供了一个框架.
IL4I1代表了提高ccRCC治疗疗效的有希望的治疗标.

关键词:

第四百一十一章没有了氨基酸代谢氨基酸代谢清细胞细胞癌是什么?机器学习是机器学习.预测得分预测得分

更多相关视频

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

相关概念视频

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.