热素升高是重症监护室急性缺血性中风患者的潜在标志物:一项回顾性观察研究
Xianming Qiu1, Lei Zhou1, Bingyun Wu2
1Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Emergency Medicine, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Jinan, Shandong Province, China.
在急性缺血性中风患者中,中性粒细胞和D-二元水平较高,表明ICU入院的可能性更高. 心脏托罗邦素I的升高与这些ICU患者的预后较差有关.
科学领域:
- 神经学 神经学
- 关键护理医学 关键护理医学
- 生物化学 生物化学
背景情况:
- 急性缺血性中风是导致残疾和死亡的主要原因.
- 识别预测中风严重程度和预后的因素对于及时干预至关重要.
- 进入重症监护室 (ICU) 意味着更严重的中风需要先进的监测和治疗.
研究的目的:
- 确定与急性缺血性中风患者状况相关的风险因素和指标.
- 为了比较在ICU中存活和不存活的缺血性中风患者之间的生化标志物.
- 确定预测急性缺血性中风患者进入ICU的预后的生物标志物.
主要方法:
- 70名急性缺血性中风患者 (27名ICU,43名神经病科) 的回顾性分析.
- 评估病史,生活方式,心电图,生化指标和炎症性细胞因子.
- 多变量逻辑回归用于确定ICU患者死亡率的预测因素.
主要成果:
- 在患有缺血性中风的ICU患者中观察到增加的中性粒细胞和D-二元水平 (p < 0.05).
- 与幸存者相比,在没有存活的ICU患者中,心脏热素I显著升高 (p <0.05,OR:29.250,95%CI:2.789306.811).
结论:
- 增加的中性粒细胞和D-二次体与急性缺血性中风的ICU入院可能性增加有关.
- 心脏托波宁I的升高似乎是急性缺血性中风的ICU患者预后不佳的重要预测因素.
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