相关实验视频

Updated: Mar 14, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.9K

构建文献衍生数据库,以使用光谱排名推理对多基因风险评分构造方法进行基准测试

Chris Sebastian, Mengxin Yu, Jin Jin

    medRxiv : the preprint server for health sciences
    |March 13, 2026
    PubMed
    概括

    基因风险评分 (PRS) 方法的基准测试对于遗传疾病预测至关重要. 这项研究系统地使用公布结果的数据库对14种PRS方法进行了排名,确定了LDpred2和AnnoPred等表现最佳的方法.

    更多相关视频

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

    Published on: June 21, 2018

    10.8K
    An R-Based Landscape Validation of a Competing Risk Model05:37

    An R-Based Landscape Validation of a Competing Risk Model

    Published on: September 16, 2022

    2.7K

    相关概念视频

    Polygenic Traits01:18

    Polygenic Traits

    11.2K
    Polygenic Traits01:18

    Polygenic Traits

    When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
    70.1K
    Relative Risk01:12

    Relative Risk

    Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
    2.4K
    Genome-wide Association Studies-GWAS01:11

    Genome-wide Association Studies-GWAS

    Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
    GWAS does not require the identification of the target gene involved in...
    16.4K
    Expected Frequencies in Goodness-of-Fit Tests01:19

    Expected Frequencies in Goodness-of-Fit Tests

    A goodness-of-fit test is conducted to determine whether the observed frequency values are statistically similar to the frequencies expected for the dataset. Suppose the expected frequencies for a dataset are equal such as when predicting the frequency of any number appearing when casting a die. In that case, the expected frequency is the ratio of the total number of observations (n)  to the number of categories (k).
    8.8K
    Heritability01:06

    Heritability

    Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
    771