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Updated: Mar 14, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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Published on: March 2, 2014

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人类RIG-I抗病毒缺陷是由被锁定在信号不活跃状态中的主导负变异引起的

Mihai Solotchi, Huie Jing, Emma Gebauer

    medRxiv : the preprint server for health sciences
    |March 13, 2026
    PubMed
    概括

    由于新型G731R变异,在COVID-19患者中发现的严重RIG-I缺陷会损害抗病毒免疫力. 这种占主导地位的负基因突变破坏了RIG-I的功能,突显了它在人类防御中的关键作用.

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