在非酒精性脂肪肝疾病中的肠道微生物群
Anastasios Mpountouridis1, Christina Tsigalou2, Ioanna Bezirtzoglou3
1Gastroenterology Department, Theagenio Cancer Hospital, Thessaloniki, Greece.
Frontiers in gastroenterology (Lausanne, Switzerland)
|March 13, 2026
概括
肠道失调,肠道细菌的不平衡,显着导致非酒精性脂肪肝疾病 (NAFLD) 的发展. 像益生菌和益生菌这样的干预措施在通过调节肠道微生物群来管理NAFLD方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 影响全球三分之一的人口,其致病因涉及肠道失调.
- 肠道微生物组通过肠肝轴影响肠道屏障完整性和肝脏免疫功能.
- 肠道微生物群的变化,包括细菌群和代谢物的变化,与NAFLD进展有关.
研究的目的:
- 探索肠道微生物组在NAFLD的发展和进展中的多方面的作用.
- 审查肠道微生物群对宿主稳定,肠道屏障功能和肝炎的影响.
- 讨论针对NAFLD管理的肠道微生物组的潜在治疗策略.
主要方法:
- 审查有关肠道微生物组和NAFLD的现有文献.
- 分析包括脂聚糖 (LPS) 转移,胆酸代谢和短链脂肪酸 (SCFA) 生产的途径.
- 检查细菌变化 (例如, Bacteroidetes, Firmicutes) 和它们与NAFLD的关联.
主要成果:
- 肠道功能失调通过增加LPS,改变胆酸代谢 (影响FXR和TGR5信号),以及降低酸盐等SCFA导致NAFLD.
- 在NAFLD患者中观察到特定的细菌变化,如增加的Bacteroidetes和减少的Firmicutes.
- 益生菌,益生菌和协生菌在NAFLD预防和治疗方面具有潜力,而便微生物群移植 (FMT) 需要进一步评估.
结论:
- 肠道微生物组是NAFLD病变的关键因素,影响肝脏脂肪,炎症和纤维化.
- 通过益生菌,益生菌和协生菌调节肠道微生物组为NAFLD提供了有前途的治疗途径.
- 需要进一步的研究,以充分阐明在NAFLD管理中像FMT这样的干预措施的有效性.
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