由Klebsiella pneumoniae连续型147共产NDM-1和OXA-48持续的医院爆发,罗马,意大利,2025年2月至3月:分子追踪和控制措施
Valerio Capitani1, Mariateresa Ceparano1, Annalisa Rosso1
1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
概括
在罗马发生的产生卡巴酶的Klebsiella pneumoniae疫情通过感染控制措施被制. 基因组监测和快速诊断对于管理在医院传播的多抗药生物体至关重要.
科学领域:
- 临床微生物学 临床微生物学
- 传染病流行病学 传染病流行病学
- 基因组监测是指基因组的监测.
背景情况:
- 产生卡巴酶的克莱布西拉肺炎 (CRKP) 在医疗保健环境中构成重大威胁.
- 爆发CRKP需要快速有效的感染预防和控制 (IPC) 策略.
- NDM-1和OXA-48碳烯酶的联合生产代表了一个具有挑战性的多药耐药生物体 (MDRO).
研究的目的:
- 为了描述CRKP在罗马一家三级医院的爆发.
- 评估IPC措施在制疫情爆发方面的有效性.
- 突出基因监测在理解CRKP传播中的作用.
主要方法:
- 追溯分析2025年2月至3月的CRKP疫情.
- 实施和评估IPC措施:患者队列,环境清洁,接触监测.
- 快速分子类型 (纳米类型) 和全基因组测序 (WGS) 用于菌株特征和植物遗传分析.
- 环境采样用于检测病原体.
主要成果:
- 在重症监护病房的10名患者被NDM-1和OXA-48共产的K. pneumoniae定居或感染.
- 九例感染是在医院获得的,通过直肠抽样查检测到.
- 在IPC措施中,最初的传播被控制了下来,但传播到其他病房发生了.
- 基因组分析证实了高风险ST147克隆的克隆传播,有区域传播的证据.
- 确定了一个单一的受污染的环境表面.
结论:
- 快速实施IPC措施至关重要,但在重症监护机构具有挑战性.
- 基因组监测与快速诊断相结合,对于实时疫情应对至关重要.
- 加强查,例行监测和严格的IPC协议对于防止MDRO在医疗机构中传播至关重要.
关键词:
CTX-M-15四个副本的四个副本.预防感染,控制和预防感染.积极监督是指积极的监督.分子类型的分子类型.疫情爆发调查调查.在 pNDM-MAR 中.repB ((R1701)) 的意思是说.更多相关视频
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