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白血球-Hitchhiking纳米药物用于敏感化铁灭症治疗

Lingyu Zhong¹, Yingfei Wang¹, Fan Zhou¹

¹State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

ACS applied materials & interfaces

|March 13, 2026

概括

这项研究引入了一种针对三阴性乳腺癌的新型细胞介导纳米医学策略. 白细胞引导的脂质体增强了向瘤的药物输送,提高了治疗效率,并通过铁灭减少了转移.

科学领域:

生物医学工程生物医学工程
纳米医学是一种纳米医学.
在瘤学瘤学.

背景情况:

三阴性乳腺癌 (TNBC) 面临着挑战,因为瘤微环境中的生物障碍限制了治疗疗效.
目前TNBC的治疗方法往往导致治疗失败和癌症复发.
开发有效的药物输送到瘤部位的策略对于改善患者的治疗结果至关重要.

研究的目的:

开发细胞介导纳米医学的体内战略,以克服TNBC中的生物障碍.
增强瘤部位的药物积累,改善转移的治疗.
研究铁灭菌诱导剂和纳米酶在癌症治疗中的协同作用.

主要方法:

开发用于静脉注射和白细胞表面粘附的E-选择因修饰脂质体.
利用白细胞炎症热带作用,以有针对性地将脂质体运送到瘤部位.
铁灭诱导体RSL3和纳米酶金纳米颗粒 (AuNPs) 在脂质体内的联合封装.
激光照射的应用以诱导协同效应并放大铁灭.

主要成果:

实现了脂质体对白细胞表面的选择性粘附,促进了有针对性的输送.
通过白细胞上车显著增强纳米药物的瘤积累.
通过饥饿疗法强化铁亡,有效抑制瘤生长和肺转移.
在激光照射下破坏了细胞营养供应和损坏了氧化还原平衡.

结论:

白血球车策略显示了在癌症治疗中向药物输送的巨大潜力.
细胞介导纳米医学为治疗各种癌症提供了更广泛的适用性,包括TNBC.
铁灭症诱导和饥饿疗法的协同作用组合为癌症治疗提供了一个有前途的方法.

关键词:

细胞介导药物递送系统是细胞介导的.铁性化 (ferroptosis) 是一种这是白血球细胞.纳米酶纳米酶是一种纳米酶.三个阴性乳腺癌.

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