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Updated: Mar 14, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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诱导TRIB2向蛋白质降解以逆转急性髓性白血病的化学抵抗

Evie Rigby1, Francesca Fasanella Masci1, Akshara Narayanan1

  • 1Wolfson Wohl Translational Cancer Research Centre, School of Cancer Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.

The Biochemical journal
|March 13, 2026
PubMed
概括

通过促进TRIB2瘤基因的降解来向TRIB2瘤基因是治疗急性髓性白血病 (AML) 的有希望的策略. 这种方法提高了化疗的有效性,并克服了AML的耐药性.

关键词:
急性骨髓性白血病 (AML) 是一种疾病.化学疗法耐药性 抗化学疗法耐药性伪基因酶是一种假基因.这就是Tribbles.乌比基蛋白质酶体系统

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