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左侧和右侧结直肠癌的不同临床和微生物概况:全面分析

Jianjiong Li¹, Buyuan Dong²

¹Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Microbiology spectrum

|March 13, 2026

概括

这项研究揭示了基于瘤位置和类型的结直肠癌 (CRC) 组织中明显的微生物差异. 这些发现表明,早期CRC检测和个性化治疗策略的潜在微生物生物标志物.

科学领域:

微生物学微生物学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

大肠直肠癌 (CRC) 在左侧 (LCC) 和右侧 (RCC) 瘤之间显示出明显的临床和预后差异.
瘤相关微生物组在CRC中的作用,按瘤侧向分层,尚不清楚.

研究的目的:

调查LCC和RCC之间的临床和微生物差异.
分析CRC患者瘤 (T) 与周围瘤 (P) 组织中的微生物特征.
为了确定CRC管理的潜在微生物生物标志物.

主要方法:

收集并分析了240个中国CRC组织样本 (瘤和周围瘤).
按瘤位置 (LCC与RCC) 和组织类型 (T与P) 分类的样本.
进行了16S rRNA测序和生物信息学分析,以检测微生物多样性和组成.

主要成果:

慢性肺癌患者年龄较大,体重较重,身高较高,瘤标志物较高 (CEA,CA199).
在微生物丰富度或LCC和RCC之间的均性方面没有显著差异;然而,观察到不同的种类和预测功能的不同丰度.
与周围瘤组织相比,瘤组织的微生物多样性较低,社区结构发生了变化.
在LCC和RCC之间的KEGG正统学家 (KO) 和正统学群集群 (COG) 中发现了显著的差异.

结论:

瘤侧向性和微生物组成是CRC的关键因素.
瘤和周围瘤组织中明显的微生物概况可以作为早期检测和治疗反应的生物标志物.
需要进一步的研究来探索这些微生物差异在CRC中的临床影响.

关键词:

结肠直肠癌是什么意思我们的肠道微生物组.在左侧结直肠癌.微生物多样性的微生物多样性在右侧结直肠癌.

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