胎儿生长限制机制和治疗方向中的活性氧物种 (综述)
Di Cheng1, Songbin Yang1, Cuilan Wang1
1Department of Obstetrics, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250000, P.R. China.
International journal of molecular medicine
|March 13, 2026
概括
胎儿生长限制 (FGR) 涉及胎盘氧化应激,由高氧化损伤标志物和改变的抗氧化防御表现出来. 抗氧化剂疗法显示出潜力,但需要进一步的临床验证来管理FGR.
科学领域:
- 围产儿医学 围产儿医学
- 生物化学 生物化学
- 分子生物学分子生物学
背景情况:
- 胎儿生长限制 (FGR) 与周围产生的不良结果有关.
- 胎盘氧化应激是FGR的关键病理因素.
- 在FGR怀孕中观察到高氧化应激标志物 (例如,马隆迪阿尔代海德,8-基-2'-脱氧氨酸) 和抗氧化防御能力受损 (例如,降低酶).
研究的目的:
- 审查胎盘氧化应激在FGR中的作用.
- 检查将氧化应激与FGR病理联系起来的分子机制.
- 评估抗氧化剂干预措施对FGR的潜力.
主要方法:
- 对FGR中胎盘氧化应激现有的文献的综述.
- 分子路径的分析,包括内质网膜应激,代谢重编程和表观遗传变化.
- 对抗氧化剂治疗的临床前和早期临床数据的评估.
主要成果:
- 氧化应激标志物在FGR中始终升高,具有补偿性抗氧化反应和降低酶活性.
- 活性氧物种的来源包括NADPH氧化酶,丁氧化酶,线粒体运输和缺血-再输液.
- 氧化应激与ER应激,代谢变化和表观遗传修饰 (例如DNA低甲基化,microRNAs) 相互作用,使胎盘功能障碍恶化.
结论:
- 在FGR的早期研究中,氨酸和氧菲林显示出前景,而维生素C和维生素E缺乏明显的益处.
- 线粒体向和经典抗氧化剂显示出临床前的潜力,但需要优化剂量和时间.
- 精心设计的临床试验对于确认FGR抗氧化剂策略的有效性和安全性至关重要.
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