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揭开分子景观:神经母细胞瘤中的长非编码RNA (评论)

Zidong Xia¹, Huishan Zhai¹, Lei Zheng¹

¹Department of Pediatric Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

Oncology reports

|March 13, 2026

概括

长非编码RNAs (lncRNAs) 是神经母细胞瘤 (NB) 发展和进展的关键驱动因素. 了解lncRNA机制为这种儿科癌症提供了新的诊断和治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

神经母细胞瘤 (NB) 是儿童癌症死亡的主要原因,目前的治疗方法面临局限性.
尽管免疫疗法和向疗法取得了进展,但超过三分之一的高风险NB患者表现出耐药性或不反应.
失调的长非编码RNA (lncRNA) 表达越来越多地与NB预后,诊断和治疗结果有关.

研究的目的:

系统地审查 lncRNAs 在神经母细胞瘤发育和进展中的分子机制.
为NB提供 lncRNAs作为新兴临床点的最新概述.
突出 lncRNAs 在开发 NB 新型诊断和治疗策略方面的潜力.

主要方法:

对调查神经母细胞瘤中lncRNA功能的研究进行系统性文献综述.
对 lncRNA 参与 NB 病变的分子机制的分析.
评估 lncRNAs 在NB管理中的当前和潜在的临床应用.

主要成果:

在神经母细胞瘤发育和进展的各个阶段,lncRNAs起着重要的作用.
特定的lncRNA与NB诊断,预后和对治疗的反应有关.
对lncRNA表达的失调是神经母细胞瘤的一个常见特征.

结论:

lncRNAs是神经母细胞瘤中关键的分子参与者.
lncRNAs作为NB早期诊断和预后的生物标志物具有前途.
针对 lncRNAs 可能导致神经母细胞瘤的新型精确治疗策略.

关键词:

生物标志物生物标志物长长的非编码RNAs.神经母细胞瘤的神经母细胞瘤有针对性的治疗.

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