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[关注的表达]德克斯梅德托米丁通过Hsp90/AKT信号传递来预防败血症相关的脑病变

Lijun Yin¹, Xuejun Chen¹, Hongbo Ji¹

¹Department of Anesthesiology, Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin 301800, P.R. China.

Molecular medicine reports

|March 13, 2026

概括

人们对西方黑斑数字中潜在的数据重复和操纵表示担忧. 该杂志发布了一份表达关切的声明,等待对科学完整性问题的进一步调查.

科学领域:

生物化学生物化学
分子生物学分子生物学
科学出版伦理学出版伦理学

背景情况:

一位读者对潜在的数据相似性提出了担忧.
具体的数字 (图. 4A, 图. 这里. 1A,图. 一个. 1B, 图. 在图中. 5A, 图. 这里. 5B) 发现明显的数据重复.

研究的目的:

为了解决有关发表的西部黑斑数据的科学完整性的担忧.
调查论文中数据呈现的潜在异常.

主要方法:

在不同数字和之前发布的数据中比较西部污染数据.
与作者联系,以了解有关观察到的数据异常的解释.

主要成果:

在图中,在西部斑点数据之间观察到惊人的相似之处. 4A和来自其他出版物的数据.
在多个图形中发现了蛋白质带的明显重复 (β-actin,分裂的caspase-3,Bcl-2).

结论:

由于科学完整性存在潜在问题,已发布"表达关切".
编辑部正在继续调查此事,因为作者没有提供回应.

关键词:

切卡结合和穿孔的发生.德克斯梅德米丁 (Dexmedetomidine) 是一种制剂.脂多糖类糖化物 (Lipopolysaccharide) 是一种脂多糖类糖.败血症相关的脑病变; Hsp90/aKT信号传递.

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