几乎所有部位的骨折都与不良结果有关:一项观察性研究
Dima A Alajlouni1,2, Dunia Alarkawi2, Thach S Tran2,3
1Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, NSW, Australia.
概括
在部,脊椎,部和前臂外的骨折 (非MOF) 显著增加后续骨折和死亡风险,与严重骨质疏松性骨折 (MOF) 相比. 所有骨折部位,包括非MOF,由于不良结果,需要临床关注.
科学领域:
- 老年学是一门学科.
- 流行病学 流行病学
- 整形外科 整形外科 整形外科
背景情况:
- FRAX模型将骨折分为主要骨质疏松性骨折 (MOF) 和非主要骨质疏松性骨折 (NonMOF).
- 有一种误解认为非MOF比MOF不那么重要,可能会忽视它们对患者结果的影响.
- 了解与不同骨折部位相关的比较风险对于全面的骨质疏松症管理至关重要.
研究的目的:
- 为了比较后续骨折和死亡风险后MOF与非MOF.
- 根据解剖学分类来分析这些风险:部,脊椎,近端和远端骨折.
- 评估所有骨折部位对不良结果的贡献.
主要方法:
- 利用了来自加拿大多中心骨质疏松研究和杜博骨质疏松流行病学研究的7568名女性和3366名60岁以上的男性的数据.
- 将初始骨折分类为MOF或NonMOF,并在解剖学上分类为部,脊椎,近端或远端.
- 在中位数的随访期内评估后续骨折发生率和死亡率.
主要成果:
- 非MOF与女性的后续骨折风险增加69%,男性的风险增加两倍,与MOF相比.
- 非MOF在两性中传递了超过30%的过度死亡率,虽然比MOF要低,但比MOF要大.
- 所有解剖学骨折部位都与随后的骨折风险有关,死亡风险从远端骨折到近端骨折,脊椎骨折和部骨折增加.
结论:
- 无论是MOF还是非MOF,都显示出后续骨折和死亡率的风险相似.
- 所有骨折部位,无论MOF分类如何,都与显著的不良结果有关.
- 临床护理指南应针对所有骨折部位,以减轻风险并改善患者的治疗结果.
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