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Updated: Aug 1, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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在缺乏TFPI的小鼠中,缺陷的脑血管发育被激活蛋白C恢复

Susan A Maroney1, Nicholas D Martinez2, Praveen Krishnamoorthy3

  • 1Versiti Blood Research Institute, Milwaukee, Wisconsin, United States.

Blood
|March 13, 2026
PubMed
概括

组织因子通路抑制剂 (TFPI) 缺乏导致由于血栓过多而导致胚胎死亡. 一个可过激活的蛋白C转基因拯救了致死性,这表明TFPI在胚胎血管生成和脑血管发育中的关键作用.

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