来自SARS-CoV-2 NAT阳性捐赠者的受体的3年合移植结果的比较
Christine E Koval1, Mohamed Eltemamy2, Nabin K Shrestha1
1Department of Infectious Diseases, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA.
概括
来自SARS-CoV-2 (COVID-19) 阳性捐赠者的脏移植显示了与负性捐赠者的3年结果相似的结果. 这包括移植的生存和病理,不管捐赠者的COVID-19严重程度如何.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 已知来自SARS-CoV-2 NAT阳性捐赠者的短期脏移植 (KT) 成功.
- 长期结果和捐助者COVID-19严重程度的影响需要进一步调查.
研究的目的:
- 为了比较SARS-CoV-2 NAT阳性,COVID-19作为死亡原因 (CoV-COD) 和NAT阴性捐赠者的受体中的1年和3年的异构移植结果.
- 评估捐赠者COVID-19状态与长期功能之间的关联.
主要方法:
- 对220名移植接受者 (KTRs) 的回顾性审查.
- 通过捐赠组对1年和3年全移植结果的比较:NAT+ (N=59),Cov-COD (N=56) 和NAT-负 (N=105).
- 对全移植活检结果和3年后估计的膜过率 (eGFR) 的分析.
主要成果:
- 在各组之间,在1年内排斥或病理方面没有显著差异.
- 3年后,患者死亡或移植损失没有显著差异.
- 在各组中类似的3年eGFR (NAT+:54.8,Cov-COD:45.6,NAT-neg:48.4mL/min/m2),在多变量分析中与Cov-捐赠者状态没有显著关联.
结论:
- 来自不同SARS-CoV-2严重程度 (NAT+,Cov-COD,NAT-neg) 的捐赠者的移植产生了可比的3年移植结果.
- 捐赠者COVID-19状态,即使COVID-19是死亡原因,也没有显著影响长期的移植生存或病理.
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