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Updated: Mar 15, 2026

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
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Published on: July 20, 2022

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缺少COG5会破坏细胞铜恒温,并导致线粒体OXPHOS功能受损

Yuwei Zhou1,2, Keyi Li2, Ruowei Zhu2

  • 1Laboratory Medicine Center, Department of Genetic and Genomic Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

PLoS genetics
|March 13, 2026
PubMed
概括

COG5蛋白质功能障碍通过增加细胞铜来损害线粒体氧化酸化 (OXPHOS),导致复杂I缺陷. 恢复COG5或降低铜水平可以挽救OXPHOS的功能.

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